NIH

New Onset Depressive Symptoms in Acute Illness (R01 Clinical Trial Not Allowed)

NIH Funding Opportunities (Notices, PA, RFA) - September 19, 2017 - 1:06pm
Funding Opportunity PA-17-488 from the NIH Guide for Grants and Contracts. The purpose of the funding opportunity announcement (FOA) is to encourage research on the etiology of depressive symptoms that occur in the context of a sudden onset acute illness. Although it is known that depressive symptoms may linger and affect functional recovery long after physical recovery from an acute insult, there is a gap in knowledge about the pathobiology that may underlie these incident depressive symptoms. A greater understanding of the etiological factors that contribute to and/or mitigate a trajectory of depressive symptoms may inform a personalized, holistic approach to managing recovery from acute illness.
Categories: NIH

New Onset Depressive Symptoms in Acute Illness (R21 Clinical Trial Not Allowed)

NIH Funding Opportunities (Notices, PA, RFA) - September 19, 2017 - 1:05pm
Funding Opportunity PA-17-487 from the NIH Guide for Grants and Contracts. The purpose of the funding opportunity announcement (FOA) is to encourage research on the etiology of depressive symptoms that occur in the context of a sudden onset acute illness. Although it is known that depressive symptoms may linger and affect functional recovery long after physical recovery from an acute insult, there is a gap in knowledge about the pathobiology that may underlie these incident depressive symptoms. A greater understanding of the etiological factors that contribute to and/or mitigate a trajectory of depressive symptoms may inform a personalized, holistic approach to managing recovery from acute illness.
Categories: NIH

NHLBI Announces Plan to Fund a Limited CARDIA Year 35 Exam

NIH Funding Opportunities (Notices, PA, RFA) - September 19, 2017 - 12:35pm
Notice NOT-HL-17-536 from the NIH Guide for Grants and Contracts
Categories: NIH

Human Heredity and Health in Africa (H3Africa): Ethical, Legal, and Societal Issues (ELSI) Collaborative Centers (U54)

NIH Funding Opportunities (Notices, PA, RFA) - September 19, 2017 - 12:13pm
Funding Opportunity RFA-RM-17-020 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages applications to establish Collaborative Centers to study ethical, legal and societal issues (ELSI) of human genome and environmental health research across the African continent. Of particular interest are projects that propose bioethical, legal, and social science analyses of new or emerging issues that affect multiple communities across the continent of Africa. These awards will support 3-5 collaborating research projects at three or more African institutions working together as a partnership to accomplish more than each project could accomplish on its own.
Categories: NIH

Human Heredity and Health in Africa (H3Africa): Ethical, Legal, and Societal Issues (ELSI) Research Program (U01)

NIH Funding Opportunities (Notices, PA, RFA) - September 19, 2017 - 12:13pm
Funding Opportunity RFA-RM-17-021 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages applications to study the ethical, legal and societal issues (ELSI) of human genome research in African populations. Of particular interest are projects that propose focused bioethical, legal, and social science analyses of new or emerging issues.
Categories: NIH

Short-term Mentored Career Enhancement Awards for Mid-Career Investigators to Integrate Basic Behavioral and Social Sciences (K18)

NIH Funding Opportunities (Notices, PA, RFA) - September 19, 2017 - 10:05am
Funding Opportunity PAR-17-486 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages applications for short-term mentored career development (K18) awards that improve synergies among researchers in basic and applied behavioral-social sciences, human subjects and model animals settings; and biomedical and behavioral-social sciences.
Categories: NIH

NIH Peer Review Online Briefings for AREA (R15) and SBIR/STTR Grant Applicants

NIH Funding Opportunities (Notices, PA, RFA) - September 19, 2017 - 9:32am
Notice NOT-OD-17-112 from the NIH Guide for Grants and Contracts
Categories: NIH

Biology Of Aging Dental, Oral And Craniofacial Tissues (R21 - Clinical Trial Not Allowed)

NIH Funding Opportunities (Notices, PA, RFA) - September 19, 2017 - 2:25am
Funding Opportunity RFA-DE-18-010 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to stimulate collaborative research to understand the biological mechanisms of aging in dental, oral, and craniofacial (DOC) tissues, as they relate to parallel processes in other tissues and organs. The areas of emphasis under this FOA include inflammation, tissue healing and regeneration, and epigenetic regulation. The overarching long-term goal of this effort is to improve oral health in older adults by addressing knowledge gaps in our understanding of the basic biology of age-associated changes in health and disease states of DOC tissues.
Categories: NIH

Biology Of Aging Dental, Oral And Craniofacial Tissues (R01 - Clinical Trial Not Allowed)

NIH Funding Opportunities (Notices, PA, RFA) - September 19, 2017 - 2:25am
Funding Opportunity RFA-DE-18-009 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to stimulate collaborative research to understand the biological mechanisms of aging in dental, oral, and craniofacial (DOC) tissues, as they relate to parallel processes in other tissues and organs. The areas of emphasis under this FOA include inflammation, tissue healing and regeneration, and epigenetic regulation. The overarching long-term goal of this effort is to improve oral health in older adults by addressing knowledge gaps in our understanding of the basic biology of age-associated changes in health and disease states of DOC tissues.
Categories: NIH

Patents and the Relative Citation Ratio: Correlations to Assess NIH Impact

NIH Extramural Research & Funding News - September 18, 2017 - 2:52pm

We previously referenced Ioannidis’ and Khoury’s “PQRST” mnemonic for describing research impact: “P” is productivity, “Q” is quality, “R” is reproducibility, “S” is sharing, and “T” is translation.  We wrote several blogs about “P,” productivity, focusing on publications, citations, and more recently the Relative Citation Ratio.  Now we’ll focus on a different kind of “P” for productivity, namely patents (which arguably are also related to “T” for translation).  We’ll also take a brief look at “S” for sharing.

In the April 7, 2017 issue of Science, Danielle Li [now with the Massachusetts Institute of Technology (MIT)], Pierre Azoulay (MIT), and Bhaven Sampat (Columbia University) published an investigation on the patent productivity of NIH grants. They identified over 365,000 grants NIH funded between 1980 and 2007, and linked them to patents. Two kinds of links were identified: “direct” links in which a patent cited an NIH grant, and “indirect” links, in which a patent cited a paper which in turn acknowledged support from an NIH grant.

The authors found that close to 10% of grants directly generate a patent. That’s remarkable!  But perhaps even more so, nearly 30% of grants generate a paper that is later cited by at least one patent. Even more remarkable, grants directly and indirectly generated patents whether they were “disease-targeted” or not, “patient-oriented” or not, or linked to a Request For Application or not. And, large proportions of grants assigned to different models directly and indirectly generated patents – models including humans, primates, rodents, invertebrates, multicellular eukaryotes, unicellular eukaryotes, prokaryotes, and viruses.

Another noteworthy feature of this paper is that the authors freely shared their data and statistical code. We took advantage of this to ask a question: do NIH-supported papers that are cited by patents have a higher Relative Citation Ratio than those that are not cited by patents? As a refresher, the Relative Citation Ratio uses citation rates to measure the influence of a publication at the article level

We identified 119,674 unique NIH grants that were funded between 1995 and 2007 and that generated at least one publication. Of these grants, 46,002 (38%) generated at least one publication that was later cited by at least one patent. The grants generated 1,241,307 publications that appeared between 1995 and 2015; of these, 103,421 (8%) were cited by at least one patent.

Figure 1 shows a box plot of the Relative Citation Ratio of papers that were or were not cited by at least one patent.  The Y-axis (Relative Citation Ratio) is log-transformed to reflect the log-normal distribution. Papers cited by a patent had a higher Relative Citation Ratio (median 1.75, IQR 0.85-3.62 compared to papers not cited by a patent median 0.97, IQR 0.46-1.91). For convenience, we drew a dotted line through the median value of RCR among the papers cited by a patent. The large dots represent the mean RCR values.

Figure 1

Figure 2 shows the Relative Citation Ratio of papers according to the number of patents citing them.  There is a gradient, with Relative Citation Ratio increasing as papers are cited by zero, one, two, three, or more than three patents (median values of 0.97, 1.46, 1.66, 1.87, and 2.40).  For convenience, a dotted line goes through the median RCR (1.46) for papers citing one patent.

Figure 2

Taken together, the data presented here suggest that the number of publications cited by a patent positively correlates with a higher relative citation ratio. In other words, when patents cite a publication, that article is also likely to be highly influential in its field.

These preliminary findings show one way we are continuing to explore research impact beyond bibliometrics. Though helpful, focusing on bibliometrics alone does not completely capture productivity and impact of our funded research programs. The analysis we present here attempts to build upon prior work by adding yet another instrument to our toolbox.

We recognize that this correlation between patent citation and relative citation ratio may be correlative, not causal. With that noted, both measures do still provide us with a glimpse into the influence of the NIH research portfolio. Our findings are consistent with prior findings showing that the relative citation ratio also correlated with post-publication peer review.

And finally, the “S,” sharing that is…

We are pleased to hear about ways researchers use our data to empirically analyze the productivity of NIH-supported research. We congratulate the authors of the Science article, and commend their willingness to share their data. We progress towards our goal of enhanced transparency and stewardship when researchers share data with each other and when funding agencies share administrative data. Ultimately, sharing information this way is how we, together, improve human health and reduce illness and disability.

Categories: NIH

Science of Behavior Change: Use-inspired Research to Optimize Adherence, Behavior Change Interventions, and Outcomes (R21)

NIH Funding Opportunities (Notices, PA, RFA) - September 18, 2017 - 1:44pm
Funding Opportunity RFA-RM-17-028 from the NIH Guide for Grants and Contracts. Supported by the NIH Common Fund (Common Fund) Science of Behavior Change (SOBC) Program, this Funding Opportunity Announcement (FOA) solicits exploratory and developmental research project applications (R21) that will further the goal of the SOBC Program to advance a mechanisms-focused, experimental medicine approach to behavior change research. Funded projects in the SOBC Research Network have developed experimental manipulations, assays, and/or measures (hereafter referred to as assays for brevity) to support an experimental medicine approach to behavior change research. The SOBC Measures Repository assays are accessible from the SOBC Research Network Open Science Framework (OSF) page at https://osf.io/zp7b4. The goal of this announcement is to leverage SOBC Measures Repository assays of putative targets in self-regulation, stress reactivity and stress resilience, and interpersonal and social processes domains to (1) engage a selected putative target(s)/mechanism(s) of action or verify target engagement of the selected target(s)/mechanism(s) of action, and (2) test the degree to which engaging the putative target(s)/mechanism(s) of action produces a short-term desired change in a health behavior. Putative targets are the mechanisms or processes hypothesized to be malleable and play a causal role in producing behavior change, including medical regimen adherence.
Categories: NIH

Science of Behavior Change: Revision Applications for Use-inspired Research to Optimize Adherence, Behavior Change Interventions, and Outcomes (R34)

NIH Funding Opportunities (Notices, PA, RFA) - September 18, 2017 - 1:44pm
Funding Opportunity RFA-RM-17-024 from the NIH Guide for Grants and Contracts. Supported by the NIH Common Fund (Common Fund) Science of Behavior Change (SOBC) Program, this Funding Opportunity Announcement (FOA) solicits competitive revision (formerly known as a competitive supplement) applications to NIH-supported clinical trials awarded as research project R34 grants. (See information about the new NIH clinical trial definition at https://osp.od.nih.gov/clinical-research/clinical-trials/.) The goal of the SOBC Program is to advance a mechanisms-focused, experimental medicine approach to behavior change research. Funded projects in the SOBC Research Network (https://commonfund.nih.gov/behaviorchange/fundedresearch) have developed experimental manipulations, assays, and/or measures (hereafter referred to as assays for brevity) to support an experimental medicine approach to behavior change research. The SOBC Measures Repository is accessible from the SOBC Research Network Open Science Framework (OSF) page at https://osf.io/zp7b4. The goal of this FOA is to accelerate the adaptation, validation, and translation of SOBC Research Network assays for use in ongoing clinical trials. This FOA calls for the integration of SOBC Research Network assays into active NIH-supported clinical trials of drugs, devices, procedures, or behavior modifications. As such, the active NIH-supported clinical trial used to respond to this FOA does not have to be a behavior change trial or identify behavior change as a primary outcome. The integration of SOBC Research Network assays into ongoing clinical trials will accelerate the development of interventions and experimental manipulations that have been shown to engage specific mechanisms of behavior change and the development of assays that verify engagement of those behavior change targets.
Categories: NIH

Science of Behavior Change: Revision Applications for Use-inspired Research to Optimize Adherence, Behavior Change Interventions, and Outcomes (U01)

NIH Funding Opportunities (Notices, PA, RFA) - September 18, 2017 - 1:43pm
Funding Opportunity RFA-RM-17-023 from the NIH Guide for Grants and Contracts. Supported by the NIH Common Fund (Common Fund) Science of Behavior Change (SOBC) Program, this Funding Opportunity Announcement (FOA) solicits competitive revision (formerly known as a competitive supplement) applications to NIH-supported clinical trials awarded as research project U01 cooperative agreements. (See information about the new NIH clinical trial definition at https://osp.od.nih.gov/clinical-research/clinical-trials/.) The goal of the SOBC Program is to advance a mechanisms-focused, experimental medicine approach to behavior change research. Funded projects in the SOBC Research Network (https://commonfund.nih.gov/behaviorchange/fundedresearch) have developed experimental manipulations, assays, and/or measures (hereafter referred to as assays for brevity) to support an experimental medicine approach to behavior change research. The SOBC Measures Repository is accessible from the SOBC Research Network Open Science Framework (OSF) page at https://osf.io/zp7b4. The goal of this FOA is to accelerate the adaptation, validation, and translation of SOBC Research Network assays for use in ongoing clinical trials. This FOA calls for the integration of SOBC Research Network assays into active NIH-supported clinical trials of drugs, devices, procedures, or behavior modifications. The active NIH-supported clinical trial used to respond to this FOA does not have to be a behavior change trial or identify behavior change as a primary outcome. The integration of SOBC Research Network assays into ongoing clinical trials will accelerate the development of interventions and experimental manipulations that have been shown to engage specific mechanisms of behavior change and the development of assays that verify engagement of those behavior change targets.
Categories: NIH

Science of Behavior Change: Revision Applications for Use-inspired Research to Optimize Adherence, Behavior Change Interventions, and Outcomes (R01)

NIH Funding Opportunities (Notices, PA, RFA) - September 18, 2017 - 1:43pm
Funding Opportunity RFA-RM-17-022 from the NIH Guide for Grants and Contracts. Supported by the NIH Common Fund (Common Fund) Science of Behavior Change (SOBC) Program, this Funding Opportunity Announcement (FOA) solicits competitive revision (formerly known as a competitive supplement) applications to NIH-supported clinical trials awarded as research project R01 grants. (See information about the new NIH clinical trial definition at https://osp.od.nih.gov/clinical-research/clinical-trials/.) The goal of the SOBC Program is to advance a mechanisms-focused, experimental medicine approach to behavior change research. Funded projects in the SOBC Research Network (https://commonfund.nih.gov/behaviorchange/fundedresearch) have developed experimental manipulations, assays, and/or measures (hereafter referred to as assays for brevity) to support an experimental medicine approach to behavior change research. The SOBC Measures Repository assays are accessible from the SOBC Research Network Open Science Framework (OSF) page at https://osf.io/zp7b4. The goal of this FOA is to accelerate the adaptation, validation, and translation of SOBC Research Network assays for use in ongoing clinical trials. This FOA calls for the integration of SOBC Research Network assays into active NIH-supported clinical trials of drugs, devices, procedures, or behavior modifications. The active NIH-supported clinical trial used to respond to this FOA does not have to be a behavior change trial or identify behavior change as a primary outcome. The integration of SOBC Research Network assays into ongoing clinical trials will accelerate the development of interventions and experimental manipulations that have been shown to engage specific mechanisms of behavior change and the development of assays that verify engagement of those behavior change targets.
Categories: NIH

NIH Science Education Partnership Award (SEPA) (R25)

NIH Funding Opportunities (Notices, PA, RFA) - September 18, 2017 - 2:38am
Funding Opportunity PAR-17-339 from the NIH Guide for Grants and Contracts. The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NIGMS R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. To this end, this funding opportunity announcement (FOA) encourages the development of innovative educational activities for pre-kindergarten to grade 12 (P-12), pre-service and in-service teachers (Teachers) and students from underserved communities with a focus on Courses for Skills Development, Research Experiences, Mentoring Activities, Curriculum or Methods Development and Outreach. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Information on current SEPA projects can be found at: https://www.nigms.nih.gov/Research/crcb/sepa/Pages/default.aspx and http://nihsepa.org. Applicants are strongly encouraged to consult with the SEPA Scientific/Research Contact to be advised on the appropriateness of the intended P-12 STEM or ISE project for SEPA program objectives and the priorities of the NIGMS.
Categories: NIH
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