This research theme includes the exploration of early developmental circumstances that may be crucial for shaping how we age, including nutrition, infectious disease, social support, education, and gene-environment interactions prenatally and during childhood. This theme is firmly rooted in understanding aging as a process that begins at conception, rather than being a discrete stage marked by having reached a specific biological age. PARC associates pursue research on the early-life determinants of mortality and health in diverse domestic and international contexts. This Chat will focus on how PARC can facilitate the use of exceptional cohort and/or multigenerational data for these research questions, stimulate comparative research on the early-life determinants of aging, facilitate collaborations between PARC associates and across affiliated centers to enhance the understanding of life-course determinants of aging and possible policy-responses that can help reduce health inequalities stemming from early-life adversities that predominantly affect some subsets of populations. REGISTER NOW.