Funding Opportunity PAR-25-353 from the NIH Guide for Grants and Contracts. Reissue of PAR-20-119. This FOA encourages applications to advance the discovery, preclinical development, and proof of concept (PoC) testing of new, rationally based candidate agents and neurostimulation approaches to treat mental disorders, substance use disorders (SUDs) or alcohol use disorder (AUD), and to develop novel ligands and circuit-engagement devices as tools to further characterize existing or to validate new drug/device targets. Partnerships between academia and industry are strongly encouraged. This FOA supports a research program of multiple projects directed toward a specific major objective, basic theme or program goal, requiring a broadly based, multidisciplinary and often long-term approach. Projects seeking support for a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies should consider the companion U01 FOA.

Funding Opportunity PAR-25-352 from the NIH Guide for Grants and Contracts. Reissue of PAR-20-118. This Notice of Funding Opportunity (NOFO) encourages applications to advance the discovery, preclinical development, and proof of concept (PoC) testing of new, rationally based candidate agents and neurostimulation approaches to treat mental disorders, substance use disorders (SUDs) or alcohol use disorder (AUD), and to develop novel ligands and circuit-engagement devices as tools to further characterize existing or to validate new drug/device targets. Partnerships between academia and industry are strongly encouraged. This NOFO using the U01 mechanism supports a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies Projects seeking support for a research program of multiple projects directed toward a specific major objective, basic theme or program goal, requiring a broadly based, multidisciplinary and often long-term approach should consider the companion U19 FOA.

Notice NOT-RM-25-001 from the NIH Guide for Grants and Contracts

Notice NOT-AG-24-031 from the NIH Guide for Grants and Contracts

Notice NOT-CA-25-021 from the NIH Guide for Grants and Contracts

Notice NOT-HL-25-004 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DK-26-007 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites applications for studies of type 1 diabetes etiology and pathogenesis using data and samples from clinical trials and studies. This opportunity is intended to fund investigative teams collaborating to answer important questions about disease mechanisms leading to improved prevention of type 1 diabetes.

Notice NOT-OD-25-063 from the NIH Guide for Grants and Contracts

Notice NOT-HL-24-032 from the NIH Guide for Grants and Contracts

Notice NOT-NS-25-009 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-25-313 from the NIH Guide for Grants and Contracts. The purpose of the NCI Pathway to Independence Award (K99/R00) program is to facilitate a timely transition of talented postdoctoral researchers with a research and/or clinical doctorate degree from mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NCI research support during this transition in order to help awardees to launch competitive, independent research careers.

Notice NOT-CA-25-022 from the NIH Guide for Grants and Contracts

Notice NOT-OD-25-064 from the NIH Guide for Grants and Contracts

Notice NOT-EY-25-005 from the NIH Guide for Grants and Contracts

Notice NOT-AG-24-032 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-AI-25-006 from the NIH Guide for Grants and Contracts. The purpose of this notice of funding opportunity (NOFO) is to support research studies of two or more vaccine adjuvants (combination adjuvants) in order to understand the mechanisms by which they work in concert. All adjuvants considered must have previously demonstrated immune modulating activity. The long-term goal of this research program is to improve the rational design of vaccines by predicting the immune profile elicited by combination adjuvants.

Funding Opportunity PAR-25-342 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support innovative and interdisciplinary research teams focused on clinical, health services, and/or community-based interventions that address health and healthcare disparities related to non-communicable and chronic diseases (NCDs) with the highest burden and mortality in Latin America and among U.S. Hispanics/Latinos. Multidisciplinary research teams would be expected to meaningfully collaborate with key partners that must include at least one PI or MPI from institutions in Latin America.

Notice NOT-AG-24-089 from the NIH Guide for Grants and Contracts

Notice NOT-OD-25-059 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-25-371 from the NIH Guide for Grants and Contracts. The purpose of this NOFO is to invite Research Project (R01) applications that propose to study the ethical, legal, and social implications (ELSI) of human genetics and genomics. Applications may propose studies using either single or mixed methods. Approaches may include but are not limited to empirical qualitative and quantitative methods, as well as conceptual, legal, and normative analyses. Direct involvement of key stakeholders where appropriate is encouraged. This Notice of Funding Opportunity (NOFO) requires a Plan for Enhancing Diverse Perspectives (PEDP) as part of the application. Applications without a PEDP will not be reviewed.